期刊
JOURNAL OF IMMUNOLOGY
卷 192, 期 10, 页码 4487-4491出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1303469
关键词
-
类别
资金
- National Institutes of Health [1U01AI095542, R01DE021255, R21CA16719]
- Infectious Disease Training [T32 AI 7172-34]
Nfil3 is viewed as an obligate transcription factor for NK cell development. However, mouse CMV(MCMV) infection recently was shown to bypass the requirement for Nfil3 by inducing the appearance of NK cells that express the MCMV- specific receptor Ly49H. Thus, signals transmitted by Ly49H and proinflammatory cytokines are sufficient to promoteNK cell differentiation in the absence of Nfil3. In this study, we report that salivary gland (SG) NK cells develop in an Nfil3-independent fashion in the steady-state in the absence of MCMV or any infection. Moreover, we show that SG NK cells have an integrin profile reminiscent of tissue-resident lymphocytes and express TRAIL for killing target cells. These results demonstrate that SG NK cells, although related to conventional NK cells, are a distinct subset of innate lymphoid cells that deviates from the conventional developmental pathway, perhaps under the influence of tissue-specific factors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据