期刊
JOURNAL OF IMMUNOLOGY
卷 193, 期 6, 页码 2971-2983出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1401037
关键词
-
类别
资金
- European Union Seventh Framework Programme (FP7) [201588]
- Ministerio de Economia y Competitividad (National R&D Internationalisation Programme, EUROSALUD, Spain) [EUS2009-03560]
- Malaria in Pregnancy Consortium through Bill and Melinda Gates Foundation [46099]
- Ministerio de Economia y Competitividad [RYC-2008-02631]
- National Health and Medical Research Council Senior Research Fellowship [GNT1043345]
- National Health and Medical Research Council Early Career Fellowship [1016443]
- ICREA Funding Source: Custom
Pregnancy triggers immunological changes aimed to tolerate the fetus, but its impact on B lymphocytes is poorly understood. In addition, exposure to the Plasmodium parasite is associated with altered distribution of peripheral memory B cell (MBC) subsets. To study the combined impact of high malaria exposure and pregnancy in B cell subpopulations, we analyzed PBMCs from pregnant and nonpregnant individuals from a malaria-nonendemic country (Spain) and from a high malaria-endemic country (Papua New Guinea). In the malaria-naive cohorts, pregnancy was associated with a significant expansion of all switched (IgD(-)) MBC and a decrease of naive B cells. Malaria-exposed women had more atypical MBC and fewer marginal zone-like MBC, and their levels correlated with both Plasmodium vivax- and Plasmodium falciparum-specific plasma IgG levels. Classical but not atypical MBC were increased in P. falciparum infections. Moreover, active atypical MBC positively correlated with proinflammatory cytokine plasma concentrations and had lower surface IgG levels than the average. Decreased plasma eotaxin (CCL11) levels were associated with pregnancy and malaria exposure and also correlated with B cell subset frequencies. Additionally, active atypical and active classical MBC expressed higher levels of eotaxin receptor CCR3 than the other B cell subsets, suggesting a chemotactic effect of eotaxin on these B cell subsets. These findings are important to understand immunity to infections like malaria that result in negative outcomes for both the mother and the newborn and may have important implications on vaccine development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据