期刊
JOURNAL OF IMMUNOLOGY
卷 193, 期 5, 页码 2207-2217出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1400411
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资金
- Academia Sinica [AS-99-CDA-L12]
- Taiwan National Science Council [100-2628-B-001-015-MY4]
- National Health Research Institutes [EX-9509NC]
Ag-primed B cells that result from an immune response can form either memory B cells or Ab-secreting plasma cells; however, the molecular machinery that controls this cellular fate is poorly understood. In this study, we show that activated B cell factor-1 (ABF-1), which encodes a basic helix-loop-helix transcriptional repressor, participates in this regulation. ABF-1 was prevalently expressed in purified memory B cells and induced by T follicular helper cell mediated signals. ABF-1 expression declined by the direct repression of B lymphocyte induced maturation protein-1 during differentiation. Ectopic expression of ABF-1 reduced the formation of Ab-secreting cells in an in vitro differentiation system of human memory B cells. Accordingly, knockdown of ABF-1 potentiates the formation of Ab-secreting cells. A transgenic mouse that expresses inducible ABF-1 in a B cell-specific manner was generated to demonstrate that the formation of germinal center and memory B cells was augmented by induced ABF-1 in an immune response, whereas the Ag-specific plasma cell response was dampened. This effect was associated with the ability of ABF-1 to limit cell proliferation. Together, our results demonstrate that ABF-1 facilitates formation of memory B cells but prevents plasma cell differentiation.
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