期刊
JOURNAL OF IMMUNOLOGY
卷 193, 期 3, 页码 1013-1016出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1400488
关键词
-
类别
资金
- National Institutes of Health [R01-AI061699]
- Charles H. Revson Foundation
Central memory (CM) CD8(+) T cells remember prior encounters because they maintain themselves through cell division in the absence of ongoing challenge (homeostatic self-renewal), as well as reproduce the CM fate while manufacturing effector cells during secondary Ag encounters (rechallenge self-renewal). We tested the consequence of conditional deletion of the bone marrow homing receptor CXCR4 on antiviral T cell responses. CXCR4-deficient CD8(+) T cells have impaired memory cell maintenance due to defective homeostatic proliferation. Upon rechallenge, however, CXCR4-deficient T cells can re-expand and renew the CM pool while producing secondary effector cells. The critical bone marrow-derived signals essential for CD8(+) T cell homeostatic self-renewal appear to be dispensable to yield self-renewing, functionally asymmetric cell fates during rechallenge.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据