期刊
JOURNAL OF IMMUNOLOGY
卷 190, 期 4, 页码 1402-1406出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1203034
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- National Cancer Institute, National Institutes of Health [5R21CA149476]
- Michigan State University
- Korea Research Council of Fundamental Science and Technology, Republic of Korea
Because NK cells lack gene-recombination machinery and are thought to be relatively short-lived, it is unclear whether NK cells can mount long-term effective recall responses to reinfections by diverse pathogens. In this article, we report that FcR gamma-deficient NK cells, which we recently identified and termed g(-)NK cells, possess distinct memory features directed by FcR-mediated Ab-dependent target recognition. The presence of g(-)NK cells was associated with prior human CMV (HMCV) infection, yet g(-)NK cell responses were not restricted to HCMV-infected target cells. In the presence of virus-specific Abs, g(-)NK cells had greatly enhanced functional capabilities, superior to conventional NK cells, and were highly responsive to cells infected with either HCMV or HSV-1. Remarkably, the g(-)NK cell subset persisted long-term at nearly constant levels in healthy individuals. Therefore, FcR gamma deficiency distinguishes an Ab-dependent memory-like NK cell subset with enhanced potential for broad antiviral responses. The Journal of Immunology, 2013, 190: 1402-1406.
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