期刊
JOURNAL OF IMMUNOLOGY
卷 191, 期 7, 页码 3553-3562出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1300081
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资金
- National Institute of Child Health and Human Development [HD45813]
- University of Washington Center for AIDS Research, a National Institutes of Health [P30 AI027757]
- National Institutes of Health Institutes and Centers: National Institute of Allergy and Infectious Diseases
- National Cancer Institute
- National Institute of Mental Health
- National Institute on Drug Abuse
- National Institute of Child Health and Human Development
- National Heart, Lung, and Blood Institute
- National Center for Complementary and Alternative Medicine
- Clinical Research Division at the Fred Hutchinson Cancer Research Center
Killer Ig-like receptors (KIRs) are innate immune receptors expressed by NK and T cells classically associated with the detection of missing self through loss of their respective MHC ligand. Some KIR specificities for allelic classical class IMHC (MHC-I) have been described, whereas other KIR receptor-ligand relationships, including those associated with nonclassical MHC-I, have yet to be clearly defined. We report in this article that KIR3DL2 and KIR2DS4 and the nonclassical Ag HLA-F, expressed as a free form devoid of peptide, physically and functionally interact. These interactions extend to include classical MHC-I open conformers as ligands, defining new relationships between KIR receptors and MHC-I. The data collectively suggest a broader, previously unrecognized interaction between MHC-I open conformers-including prototypical HLA-F-and KIR receptors, acting in an immunoregulatory capacity centered on the inflammatory response.
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