期刊
JOURNAL OF IMMUNOLOGY
卷 191, 期 6, 页码 3025-3036出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1202222
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资金
- Netherlands Organization for Scientific Research [912-04-032]
- Top Institute Pharma [T3-112]
- Dutch Cancer Society [NKI 2008-4028]
Various cell types can produce the chemokine CXCL10 in response to IFN-gamma stimulation. CXCL10 is generally viewed as a proinflammatory chemokine that promotes recruitment of CD8(+) and Th1-type CD4(+) effector T cells to infected or inflamed nonlymphoid tissues. We show that CXCL10 plays a role during CD8(+) T cell priming in the mouse. Genome-wide expression profiling revealed the Cxcl10 gene as a target of CD27/CD70 costimulation in newly activated CD8(+) T cells. CD27/CD70 costimulation is known to promote activated T cell survival, but CXCL10 did not affect survival or proliferation of primed CD8(+) T cells in vitro. Accordingly, CXCL10 could not fully rescue CD27 deficiency in mice infected with influenza virus. Rather, CXCL10 acted as chemoattractant for other activated CD8(+) T cells. It signaled downstream of CD27 in a paracrine fashion to promote generation of the CD8(+) effector T cell pool in the Ag-draining lymph nodes. Consistently, CD8(+) T cells required expression of the CXCL10 receptor CXCR3 for their clonal expansion in a CD27/CD70-dependent peptide-immunization model. Our findings indicate that CXCL10, produced by primed CD8(+) T cells in response to CD27/CD70 costimulation, signals to other primed CD8(+) T cells in the lymph node microenvironment to facilitate their participation in the CD8(+) effector T cell pool.
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