期刊
JOURNAL OF IMMUNOLOGY
卷 190, 期 8, 页码 3849-3853出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1202760
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资金
- Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research
A controversy has recently emerged regarding the location of the cellular pool of the adapter linker for activation of T cells (LAT) that participates in propagation of signals downstream of the TCR. In one model phosphorylation and direct recruitment of cell surface LAT to activation-induced microclusters is critical for T cell activation, whereas in the other model vesicular, but not surface, LAT participates in these processes. By using a chimeric version of LAT that can be tracked via an extracellular domain, we provide evidence that LAT located at the cell surface can be recruited efficiently to activation-induced microclusters within seconds of TCR engagement. Importantly, we also demonstrate that this pool of LAT at the plasma membrane is rapidly phosphorylated. Our results provide support for the model in which the cell utilizes LAT from the cell surface for rapid responses to TCR stimulation. The Journal of Immunology, 2013, 190: 3849-3853.
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