4.6 Article

Thymic Stromal Lymphopoietin Amplifies the Differentiation of Alternatively Activated Macrophages

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JOURNAL OF IMMUNOLOGY
卷 190, 期 3, 页码 904-912

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AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1201808

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  1. National Institutes of Health [AI68731, AR55695, AR56113, HL098067]
  2. Asthma and Allergy Foundation of America

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The epithelial-derived cytokine thymic stromal lymphopoietin (TSLP) has been associated with the promotion of type 2 inflammation and the induction of allergic disease. In humans TSLP is elevated in the lungs of asthma patients and in the lesional skin of individuals with atopic dermatitis, whereas mice lacking TSLP responses are refractory to models of Th2-driven allergic disease. Although several cell types, including dendritic cells, basophils, and CD4 T cells, have been shown to respond to TSLP, its role in macrophage differentiation has not been studied. Type 2 cytokines (i.e., IL-4 and IL-13) can drive the differentiation of macrophages into alternatively activated macrophages (aaM Phi s, also referred to as M2 macrophages). This population of macrophages is associated with allergic inflammation. We therefore reasoned that TSLP/TSLPR signaling may be involved in the differentiation and activation of aaM Phi s during allergic airway inflammation. In this study, we report that TSLP changes the quiescent phenotype of pulmonary macrophages toward an aaM Phi phenotype during TSLP-induced airway inflammation. This differentiation of airway macrophages was IL-13-, but not IL-4-, dependent. Taken together, we demonstrate in this study that TSLP/TSLPR plays a significant role in the amplification of aaM Phi polarization and chemokine production, thereby contributing to allergic inflammation. The Journal of Immunology, 2013, 190: 904-912.

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