期刊
JOURNAL OF IMMUNOLOGY
卷 188, 期 11, 页码 5389-5396出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1102808
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资金
- National Institutes of Health [T32 AI070099, R21 AI090700]
- Department of Defense [W81WWXWH-10-1-0185]
The signals required to generate long-lived plasma cells remain unresolved. One widely cited model posits that long-lived plasma cells derive from germinal centers (GCs) in response to T cell-dependent (TD) Ags. Thus, T cell-independent (TI) Ags, which fail to sustain GCs, are considered ineffective at generating long-lived plasma cells. However, we show that long-lived hapten-specific plasma cells are readily induced without formation of GCs. Long-lived plasma cells developed in T cell-deficient mice after a single immunization with haptenated LPS, a widely used TI Ag. Long-lived plasma cells also formed in response to TD Ag when the GC response was experimentally prevented. These observations establish that long-lived plasma cells are induced in both TI and TD responses, and can arise independently of B cell maturation in GCs. The Journal of Immunology, 2012, 188: 5389-5396.
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