期刊
JOURNAL OF IMMUNOLOGY
卷 188, 期 6, 页码 2669-2676出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1100529
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资金
- Deutsche Forschungsgemeinschaft [SFB TR52 TPA1, SCHM 1014/5-1]
- DFG [Graduiertenkolleg 1043]
- Forschungszentrum Immunologie of the University Medical Center
- Asthma Core Facility
- Johannes Gutenberg University Mainz
- Grant Agency of the Czech Republic [P302/11/ J029]
- Research Center of the Ministry of Education, Youth, and Sports of the Czech Republic [LC06009]
Ticks developed a multitude of different immune evasion strategies to obtain a blood meal. Sialostatin L is an immunosuppressive cysteine protease inhibitor present in the saliva of the hard tick Ixodes scapularis. In this study, we demonstrate that sialostatin L strongly inhibits the production of IL-9 by Th9 cells. Because we could show recently that Th9-derived IL-9 is essentially involved in the induction of asthma symptoms, sialostatin L was used for the treatment of experimental asthma. Application of sialostatin L in a model of experimental asthma almost completely abrogated airway hyperresponsiveness and eosinophilia. Our data suggest that sialostatin L can prevent experimental asthma, most likely by inhibiting the IL-9 production of Th9 cells. Thus, alternative to IL-9 neutralization sialostatin L provides the basis for the development of innovative therapeutic strategies to treat asthma. The Journal of Immunology, 2012, 188: 2669-2676.
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