期刊
JOURNAL OF IMMUNOLOGY
卷 189, 期 1, 页码 28-32出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1200507
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资金
- Perelman School of Medicine, University of Pennsylvania
- National Blood Foundation
- American Society of Hematology
- National Institutes of Health [R01AI085160, R01HL107589, R01HL111501, K08HL086503]
- American Society of Nephrology/American Society of Transplantation
- Cancer Research Institute Predoctoral Emphasis Pathway in Tumor Immunology training grant
To ensure immune tolerance, regulatory T cell (Treg) numbers must be maintained by cell division. This process has been thought to be strictly dependent on the Treg TCR interacting with MHC class II. In this study, we report that Treg division does not absolutely require cell-autonomous TCR signaling in vivo, depending on the degree of IL-2-mediated stimulation provided. At steady state IL-2 levels, Tregs require cell-autonomous TCR signaling to divide. However, when given exogenous IL-2 or when STAT5 is selectively activated in Tregs, Treg division can occur independently of MHC class II and TCR signaling. Thus, depending on the amount of IL-2R stimulation, a wide range of TCR signals supports Treg division, which may contribute to preservation of a diverse repertoire of Treg TCR specificities. These findings also have therapeutic implications, as TCR signaling by Tregs may not be required when using IL-2 to increase Treg numbers for treatment of inflammatory disorders. The Journal of Immunology, 2012, 189: 28-32.
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