期刊
JOURNAL OF IMMUNOLOGY
卷 186, 期 10, 页码 5801-5806出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1100119
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资金
- National Institutes of Health [AI038339]
- University of Chicago
Thymocytes expressing the NKT cell semi-invariant alpha beta TCR are thought to undergo agonist interactions with CD1d ligands prior to expressing promyelocytic leukemia zinc finger (PLZF), a broad complex, tramtrack, bric-a-brac, poxvirus, and zinc finger transcription factor that directs acquisition of the effector program of these innate-like T cells. Whether PLZF can mediate this effector conversion independently of agonist signaling has not been investigated. We demonstrated that transgenic (Tg) expression of PLZF under the CD4 promoter induced the innate effector program in two different MHC class II-restricted TCR-Tg Rag1(-/-) models examined. In CD4 thymocytes expressing a fixed Tg TCR beta-chain, the associated TCR alpha sequences in wild-type and PLZF-Tg mice overlapped extensively, further demonstrating that PLZF could induce the effector program in most CD4 T cells that would normally be selected as naive cells. In contrast, PLZF altered the negative selection of thymocytes expressing TCR beta-chains reactive against several retroviral superantigens. Thus, PLZF is remarkable in that it is a transcription factor capable of inducing an effector program in the absence of T cell agonist interactions or cell division. Its expression may also enhance the survival of agonist-signaled thymocytes. The Journal of Immunology, 2011, 186: 5801-5806.
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