期刊
JOURNAL OF IMMUNOLOGY
卷 186, 期 12, 页码 7187-7194出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1100412
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资金
- National Institutes of Health [K08 CA133185, RO1DK091191]
- American Recovery and Reinvestment Act Supplement to the University of Michigan's Cancer Center [P30 CA46592-22S3]
- Tom Liu Memorial Fund
- Jeffrey Colby Colon Cancer Research Fund
The nucleotide-binding oligomerization domain-like receptor (NLR) family member, Nlrp6, has been implicated in inflammasome signaling to activate caspase-1, which is essential for the production of mature IL-1 beta and IL-18. However, a function for Nlrp6 in vivo has never been demonstrated. Due to the relative high expression of Nlrp6 in intestinal tissue, we hypothesized that Nlrp6 has a role in intestinal homeostasis. Indeed, Nlrp6-deficient mice are more susceptible to chemically induced colitis as well as colitis-induced tumorigenesis than wild-type (WT) mice. Nlrp6-deficient mice exhibited significantly more inflammation within the colon than WT mice after dextran sulfate sodium treatment. Their inability to resolve inflammation and repair damaged epithelium as efficiently as WT mice resulted in prolonged increases in epithelial proliferative activity that likely underlie the increased propensity for tumors in these mice during chronic inflammation. We further show that the activity of Nlrp6 in hematopoietic cells is critical for protection against inflammation-related colon tumorigenesis. This study highlights the importance of NLR function in maintaining intestinal homeostasis to prevent the development of aberrant inflammation and tumor development within the colon. The Journal of Immunology, 2011, 186: 7187-7194.
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