期刊
JOURNAL OF IMMUNOLOGY
卷 186, 期 7, 页码 4340-4346出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1003722
关键词
-
类别
资金
- Hungarian Rosztoczy Foundation
- National Institutes of Health [P30DA015663, RO1-GM084125]
- Department of Surgery of the New Jersey Medical School
- American Heart Association [AHA06352230N]
Classically, sympathetic and parasympathetic systems act in opposition to maintain the physiological homeostasis. In this article, we report that both systems work together to restrain systemic inflammation in life-threatening conditions such as sepsis. This study indicates that vagus nerve and cholinergic agonists activate the sympathetic noradrenergic splenic nerve to control systemic inflammation. Unlike adrenalectomy, splenectomy and splenic neurectomy prevent the anti-inflammatory potential of both the vagus nerve and cholinergic agonists, and abrogate their potential to induce splenic and plasma norepinephrine. Splenic nerve stimulation mimics vagal and cholinergic induction of norepinephrine and re-establishes neuromodulation in alpha 7 nicotinic acetylcholine receptor (alpha 7nAChR)-deficient animals. Thus, vagus nerve and cholinergic agonists inhibit systemic inflammation by activating the noradrenergic splenic nerve via the alpha 7nAChR nicotinic receptors. alpha 7nAChR represents a unique molecular link between the parasympathetic and sympathetic system to control inflammation. The Journal of Immunology, 2011, 186: 4340-4346.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据