期刊
JOURNAL OF IMMUNOLOGY
卷 187, 期 10, 页码 5246-5254出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1101113
关键词
-
类别
资金
- National Institutes of Health of the National Center for Research Resources [IP20RR18754]
- National Science Foundation [IOS-0641382]
TCR mu is an unconventional TCR that was first discovered in marsupials and appears to be absent from placental mammals and nonmammals. In this study, we show that TCRm is also present in the duckbill platypus, an egg-laying monotreme, consistent with TCR mu being ancient and present in the last common ancestor of all extant mammals. As in marsupials, platypus TCR mu is expressed in a form containing double V domains. These V domains more closely resemble Ab V than that of conventional TCR. Platypus TCR mu differs from its marsupial homolog by requiring two rounds of somatic DNA recombination to assemble both Vexons and has a genomic organization resembling the likely ancestral form of the receptor genes. These results demonstrate that the ancestors of placental mammals would have had TCRm but it has been lost from this lineage. The Journal of Immunology, 2011, 187: 5246-5254.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据