期刊
JOURNAL OF IMMUNOLOGY
卷 185, 期 2, 页码 803-807出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1000661
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资金
- Juvenile Diabetes Research Foundation International
- American Diabetes Association
Recent convincing data have shown that naturally occurring CD8(+) CD122(+) T cells are also regulatory T cells. Paradoxically, CD8(+) CD122(+) T cells have been well described as memory T cells. Given their critical role in tolerance versus long-term immunity, it is important to reconcile this profound dichotomy. In this study, we reported that CD8(+) CD122(+) T cells contain both programmed death-1 (PD-1) 2 and PD-1(+) populations. It was CD8(+) CD122(+) PD-1(+) T cells, but not their PD-1(-) counterparts, that suppressed T cell responses in vitro and in vivo. This suppression was largely dependent on their production of IL-10. Moreover, the costimulatory signaling of both CD28 and PD-1 is required for their optimal IL-10 production. In contrast, Ag-specific CD8(+) CD122(+) PD-1 2 T cells were bona fide memory T cells. Thus, CD8(+) CD122(+) T cells can be either regulatory T or memory T cells, depending on their PD-1 expression and Ag specificity. This study reconciles previously contradictory findings and has important implications for tolerance induction. The Journal of Immunology, 2010, 185: 803-807.
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