期刊
JOURNAL OF IMMUNOLOGY
卷 185, 期 4, 页码 2044-2050出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1000017
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资金
- Brazilian National Research Council (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- Rio de Janeiro State Science Foundation (Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro)
- Programa Institutos Nacionais de Ciencia e Tecnologia, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
Clearance of apoptotic exudate neutrophils (efferocytosis) induces either pro-or anti-inflammatory responses in mouse macrophages depending on host genetic background. In this study, we investigated whether neutrophil efferocytosis induces a stable macrophage phenotype that could be recalled by late restimulation with LPS. Bone marrow-derived macrophages previously stimulated by pro-but not anti-inflammatory neutrophil efferocytosis expressed a regulatory/M2b phenotype characterized by low IL-12 and high IL-10 production following restimulation, increased expression ofLIGHT/TNFsuperfamily 14, Th2-biased T cell responses, and permissive replication of Leishmania major. Induction of regulatory/M2b macrophages required neutrophil elastase activity and was partially dependent on TLR4 signaling. These results suggested that macrophage differentiation to a regulatory phenotype plays a role in resolution of inflammation but could contribute to increased humoral Ab responses and parasite persistence in the infected host. The Journal of Immunology, 2010, 185: 2044-2050.
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