期刊
JOURNAL OF IMMUNOLOGY
卷 185, 期 10, 页码 5723-5731出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1001612
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资金
- National Institutes of Health
- Pennsylvania Department of Health
Unlike conventional alpha beta T cells, which preferentially reside in secondary lymphoid organs for adaptive immune responses, various subsets of unconventional T cells, such as the gamma delta T cells with innate properties, preferentially reside in epithelial tissues as the first line of defense. However, mechanisms underlying their tissue-specific development are not well understood. We report in this paper that among different thymic T cell subsets fetal thymic precursors of the prototypic skin intraepithelial V gamma 3(+) T lymphocytes (sIELs) were selected to display a unique pattern of homing molecules, including a high level of CCR10 expression that was important for their development into sIELs. In fetal CCR10-knockout mice, the V gamma 3(+) sIEL precursors developed normally in the thymus but were defective in migrating into the skin. Although the earlier defect in skin-seeding by sIEL precursors was partially compensated for by their normal expansion in the skin of adult CCR10-knockout mice, the V gamma 3(+) sIELs displayed abnormal morphology and increasingly accumulated in the dermal region of the skin. These findings provide definite evidence that CCR10 is important in sIEL development by regulating the migration of sIEL precursors and their maintenance in proper regions of the skin and support the notion that unique homing properties of different thymic T cell subsets play an important role in their peripheral location. The Journal of Immunology, 2010, 185: 5723-5731.
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