期刊
JOURNAL OF IMMUNOLOGY
卷 185, 期 5, 页码 2659-2664出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1000522
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资金
- National Institutes of Health [5 RO1 AI039246, 1 PO1 AI078897, 5 RO1 AI067706, RO1 DK074500]
- Glaxo-Smith Kline
- Marie Curie International Outgoing Fellowship [220044]
- National Institutes of Health Transfusion Biology and Medicine [5T32HL066987-09]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL066987] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI039246, R01AI067706, P01AI078897] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK074500] Funding Source: NIH RePORTER
Since the original proposal by Fearon and Locksley (Fearon and Locksley. 1996. Science 272: 50-53) that the complement system linked innate and adaptive immunity, there has been a rapid expansion of studies on this topic. With the advance of intravital imaging, a number of recent papers revealed an additional novel pathway in which complement C3 and its receptors enhance humoral immunity through delivery of Ag to the B cell compartment. In this review, we discuss this pathway and highlight several novel exceptions recently found with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and uptake by macrophages, and the capture of virus by dendritic cells residing in the medullary compartment of peripheral lymph nodes. The Journal of Immunology, 2010, 185: 2659-2664.
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