期刊
JOURNAL OF IMMUNOLOGY
卷 185, 期 3, 页码 1375-1378出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0903369
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资金
- National Institutes of Health [R01 AI090901]
- American Heart Association [09GRNT2010084]
- American Lung Association
Th cells that produce IL-17 (Th17 cells) are a distinct subset of Th cells implicated in several autoimmune diseases. Although CD28-B7 interaction has been shown to be involved in Th17 differentiation in vitro, the role of CTLA-4 in controlling Th17 development is completely unknown. We report in this paper that blocking the CTLA-4-B7 interaction potentiates Th17 cell differentiation in vitro and in vivo. Furthermore, blocking CTLA-4-B7 interaction in vivo confers the susceptibility of experimental autoimmune myocarditis to CD28(-/-) mice or increases the severity of experimental autoimmune myocarditis in wild-type mice. The enhanced disease susceptibility is mediated by heightened Th17 responses. With these results, we are the first to demonstrate that CTLA-4-B7 interaction inhibits Th17 differentiation in vitro and in vivo and suppresses Th17-mediated autoimmunity. The Journal of Immunology, 2010, 185: 1375-1378.
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