期刊
JOURNAL OF IMMUNOLOGY
卷 184, 期 10, 页码 5678-5685出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0903854
关键词
-
类别
资金
- Institut Pasteur
- Fondation pour la Recherche Medicale
- Arthritis Fondation Courtin
TLR9 is expressed in cells of the innate immune system, as well as in B lymphocytes and their progenitors. We investigated the effect of the TLR9 ligand CpG DNA on the proliferation of pro-B cells. CpG DNA inhibits the proliferation of pro-B, but not pre-B, cells by inducing caspase-independent cell death through a pathway that requires the expression of cathepsin B. This pathway is operative in Rag-deficient mice carrying an SP6 transgene, in which B lymphopoiesis is compromised, to reduce the size of the B lymphocyte precursor compartments in the bone marrow. Thus, TLR9 signals can regulate B lymphopoiesis in vivo. The Journal of Immunology, 2010, 184: 5678-5685.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据