期刊
JOURNAL OF IMMUNOLOGY
卷 185, 期 9, 页码 5188-5197出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1001990
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- Swiss Federal Institute of Technology Zurich
- Swiss National Science Foundation [310030-113947]
The mechanisms of how Th cells promote CD8(+) T cell responses during viral infections are largely unknown. In this study, we unraveled the mechanisms of T cell help for CD8(+) T cell responses during vaccinia virus infection. Our results demonstrate that Th cells promote vaccinia virus-specific CD8(+) T cell responses via two interconnected synergistic pathways: First, CD40L expressed by activated CD4(+) T cells instructs dendritic cells to produce bioactive IL-12p70, which is directly sensed by Ag-specific CD8(+) T cells, resulting in increased IL-2R alpha expression. Second, Th cells provide CD8(+) T cells with IL-2, thereby enhancing their survival. Thus, Th cells are at the center of an important communication loop with a central role for IL-2/IL-2R and bioactive IL-12. The Journal of Immunology, 2010, 185: 5188-5197.
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