期刊
JOURNAL OF IMMUNOLOGY
卷 185, 期 9, 页码 5048-5055出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1000134
关键词
-
类别
资金
- Cancer Research UK
- Medical Research Council
- Wellcome Trust
- Medical Research Council [G0400767] Funding Source: researchfish
- MRC [G0400767] Funding Source: UKRI
In the CT26 BALB/c murine model of colorectal carcinoma, depletion of regulatory T cells (Tregs) prior to tumor inoculation results in protective immunity to both CT26 and other BALB/c-derived tumors of diverse histological origin. In this paper, we show that cross-protection can be conferred by adoptively transferred CD8(+) CTLs. Other schedules for inducing immunity to CT26 have been described, but they do not lead to cross-protection. We show that Treg ablation facilitates the development of new CTL specificities that are normally cryptic, and have mapped the root epitope of one of these responses. This work has allowed us to demonstrate how the specificity of CTL responses to tumor Ags can be controlled via differential suppression of CTL specificities by Tregs, and how this can result in very different physiological outcomes. The Journal of Immunology, 2010, 185: 5048-5055.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据