期刊
JOURNAL OF IMMUNOLOGY
卷 184, 期 12, 页码 6731-6738出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1000295
关键词
-
类别
资金
- Agence Nationale de la Recherche sur le SIDA [R05121GS]
- Agence Nationale de la Recherche [A05130GS]
- Institut National de la Sante et de la Recherche Medicale
- Universite de Nantes
The impact of MHC phenotype on the shaping of the peripheral naive T cell repertoire in humans remains unknown. To address this, we compared the frequency and antigenic avidity of naive T cells specific for immunodominant self-, viral, and tumor Ags presented by a human MHC class I allele (HLA-A*02, referred to as A2) in individuals expressing or not this allele. Naive T cell frequencies varied from one Ag specificity to another but were restrained for a given specificity. Although A2-restricted T cells showed similar repertoire features and antigenic avidities in A2(+) and A2(-) donors, A2 expression had either a positive, neutral, or negative impact on the frequency of A2-restricted naive CD8 T cells, depending on their fine specificity. We also identified in all donors CD4 T cells specific for A2/peptide complexes, whose frequencies were not affected by MHC class I expression, but nevertheless correlated with those of their naive CD8 T cell counterparts. Therefore, both selection by self- MHC and inherent TCR reactivity regulate the frequency of human naive T cell precursors. Moreover this study also suggests that T cell repertoire shaping by a given self- MHC allele is dispensable for generation of immunodominant T cell responses restricted by this particular allele. The Journal of Immunology, 2010, 184: 6731-6738.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据