期刊
JOURNAL OF IMMUNOLOGY
卷 184, 期 1, 页码 21-25出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0902369
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资金
- National Institutes of Health [R01-HL36003, HL51014]
- American Heart Association [0835481N]
- National Institutes of Health Medical Scientist Training Program [T32-GM07205STP]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL036003, R01HL051014] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007205] Funding Source: NIH RePORTER
MicroRNAs (miRNAs) pair with target sequences in the 3' untranslated region of mRNAs to posttranscriptionally repress gene expression. In this study, we report that TNF-mediated induction of endothelial adhesion molecules can be regulated by miRNAs that are induced by TNF. Specifically, E-selectin and ICAM-1 are targets of TNF-induced miRNAs miR-31 and miR-17-3p, respectively. Specific antagonism of these TNF-induced miRNAs increased neutrophil adhesion to cultured endothelial cells. Conversely, transfections with mimics of these miRNAs decreased neutrophil adhesion to endothelial cells. These data suggest that miRNAs provide negative feedback control of inflammation. The Journal of Immunology, 2010, 184: 21-25.
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