期刊
JOURNAL OF IMMUNOLOGY
卷 183, 期 4, 页码 2435-2443出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0900568
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资金
- National Institutes of Health [NS038037, AI043458, NS23132]
- National MS Society
- Nancy Davis Foundation
- National Institute of Allergy and Infectious Diseases [F32AI075761]
Although the physiologic pathways that control regulatory T cells (Foxp3-expressing regulatory T cells, IL-10-secreting Tr1 cells) and Th17 cells in rodents have been defined, the factors that control these differentiation pathways in humans are not well understood. In this study, we show that IL-27 promotes the differentiation of IL-10-secreting Tr1 cells while inhibiting Th17 generation and molecules associated with Th17 function. Furthermore, IL-27 inhibits IL-17-polarizing cytokines on dendritic cells, which in turn decrease IL-17 secretion from T cells. Our results demonstrate that IL-27 plays a key role in human T cells by promoting IL-10-secreting Tr1 cells and inhibiting Th17 cells and thus provides a dual regulatory mechanism to control auto-immunity and tissue inflammation. The Journal of Immunology, 2009, 183: 2435-2443.
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