期刊
JOURNAL OF IMMUNOLOGY
卷 183, 期 11, 页码 7523-7530出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0803828
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- Ministry of Education, Culture, Sports, Science, and Technology (Japan)
- National Institute of Biomedical Innovation (NIBIO)
- RIKEN Yokohama Institute
Effector Th17 cells are a major source of IL-17, a critical inflammatory cytokine in autoimmune diseases and in host defenses during bacterial infections. Recently, splenic lymphoid tissue inducer-like cells have been reported to be a source of T cell independent IL-17. In this study, we report that the immune system contains a unique set of natural occurring IL-17 producing cell, natural Th17 (nTh17), which area memory-like T cell subset. The nTh17 cells can develop in the absence of the IL-6/STAT3 signaling axis required by inducible Th17 cells. The nTh17 cell population is distinct from conventional inducible Th17 cells, since nTh17 cells express substantial amounts of IL-17A (IL-17), but not IL-7F, under the control of the master regulator, ROR gamma t The nTh17 cells simultaneously produce IFN-gamma. DO11.10 transgenic mice with a Rag(-/-) background (DO11.10 Rag(-/-)) lack nTh17 cells, and, following intranasal administration of OVA, IL-17-dependent neutrophil infiltration occurs in DO11.10 transgenic mice, but not in DO11.10 Rag(-/-) mice. The impaired neutrophil-dependent airway response is restored by adaptive transfer of nTh17 cells into DO11.10 Rag(-/-) mice. These results demonstrate that a novel T cell subset, nTh17, facilitates the early phase of Ag-induced airway responses and host defenses against pathogen invasion before the establishment of acquired immunity. The Journal of Immunology, 2009, 183: 7523-7530.
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