期刊
JOURNAL OF IMMUNOLOGY
卷 183, 期 9, 页码 5622-5629出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0901772
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资金
- Jean Shanks Foundation
- Great Ormond Street Hospital Childrens Charity [V1223] Funding Source: researchfish
Professional phagocytosis in mammals is considered to be performed exclusively by myeloid cell types. In this study, we demonstrate, for the first time, that a mammalian lymphocyte subset can operate as a professional phagocyte. By using confocal microscopy, transmission electron microscopy, and functional Ag presentation assays, we find that freshly isolated human peripheral blood gamma delta T cells can phagocytose Escherichia coli and 1 mu m synthetic beads via Ab opsonization and CD16 (Fc gamma RIII), leading to Ag processing and presentation on MHC class II. In contrast, other CD16(+) lymphocytes, i.e., CD16(+)/CD56(+) NK cells, were not capable of such functions. These findings of distinct myeloid characteristics in gamma delta T cells strongly support the suggestion that gamma delta T cells are evolutionarily ancient lymphocytes and have implications for our understanding of their role in transitional immunity and the control of infectious diseases and cancer. The Journal of Immunology, 2009, 183: 5622-5629.
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