期刊
JOURNAL OF IMMUNOLOGY
卷 183, 期 7, 页码 4675-4681出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0901533
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资金
- National Institutes of Health [R01 A142269, R01 A149954]
- Rheuminations
The origin and function of human double negative (DN) TCR-alpha beta(+) T cells is unknown. They are thought to contribute to the pathogenesis of systemic lupus erythematosus because they expand and accumulate in inflamed organs. In this study, we provide evidence that human TCR-alpha beta(+) CD4(-) CD8(-) DN T cells can derive from activated CD8(+) T cells. Freshly isolated TCR-alpha beta(+) DN T cells display a distinct gene expression and cytokine production profile. DN cells isolated from peripheral blood as well as DN cells derived in vitro from CD8(+) T cells produce a defined array of proinflarnmatory mediators that includes IL-1 beta, IL-17, IFN-gamma, CXCL3, and CXCL2. These results indicate that, upon activation, CD8(+) T cells have the capacity to acquire a distinct phenotype that grants them inflammatory capacity. The Journal of Immunology, 2009, 183: 4675-4681.
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