期刊
JOURNAL OF IMMUNOLOGY
卷 183, 期 6, 页码 3788-3799出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0804004
关键词
-
类别
The mechanisms regulating systemic and mucosal IgA responses in the respiratory tract are incompletely understood. Using virus-like particles loaded with single-stranded RNA as a ligand for TLR7, we found that systemic vs mucosal IgA responses in mice were differently regulated. Systemic IgA responses following s.c. immunization were T cell independent and did not require TACI or TGF beta, whereas mucosal IgA production was dependent on Th cells, TACI, and TGF beta. Strikingly, both responses required TLR7 signaling, but systemic IgA depended upon TLR7 signaling directly to B cells whereas mucosal IgA required TLR7 signaling to lung dendritic cells and alveolar macrophages. Our data show that IgA switching is controlled differently according to the cell type receiving TLR signals. This knowledge should facilitate the development of IgA-inducing vaccines. The Journal of Immunology, 2009, 183: 3788-3799.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据