期刊
JOURNAL OF IMMUNOLOGY
卷 183, 期 3, 页码 1838-1845出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0901066
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资金
- Deutsche Forschungsgerneinschaft [1769/1-1]
- Deutsche Jose Carreras Leukamie-Stiftung (German Jose Carreras Leukemia Foundation) [07/10]
- Deutscher Akademischer Austauschdienst [D/08/11870]
Human B cells are currently not known to produce the proapoptotic protease granzyme B (GrB) in physiological settings. We have discovered that BCR stimulation with either viral Ags or activating Abs in the context of the acute phase cytokine IL-21 can induce the secretion of substantial amounts of GrB by human B cells. Importantly, GrB response to viral Ags was significantly stronger in B cells from subjects recently vaccinated against the corresponding viruses as compared with unvaccinated subjects. GrB-secreting B cells featured a homogeneous CD19(+)CD20(+)CD27(-)CD38(-)IgD(-) phenotype, improved survival, and enhanced expression of costimulatory, Ag-presenting and cell-adhesion molecules. B cell-derived GrB was enzymatically active and its induction required the activation of similar signaling pathways as those in CTLs. Our findings suggest that GrB-secreting B cells support the early antiviral immune response against viruses with endosomal entry pathways, thereby counteracting overwhelming viral replication at the beginning of an infection until virus-specific T cells from draining lymph nodes arrive at the site of infection. Our data may also explain the elevated serum GrB levels found in the early phase of various viral diseases. The Journal of Immunology, 2009, 183: 1838-1845.
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