期刊
JOURNAL OF IMMUNOLOGY
卷 183, 期 10, 页码 6395-6402出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0900311
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资金
- VICI [918.56.612]
- Netherlands Organization for Scientific Research
- Deutsche Forschungsgemeinschaft, DFG [MA1567/8-1, SFB621-A1]
T cells are imprinted to express tissue-specific homing receptors upon activation in tissue-draining lymph nodes, resulting in their migration to the site of Ag entry. Expression of gut-homing molecules alpha(4)beta(7), and CCR9 is induced by retinoic acid, a vitamin A metabolite produced by retinal dehydrogenases, which are specifically expressed in dendritic cells as well as stromal cells in mucosa-draining lymph nodes. In this study, we demonstrate that mesenteric lymph node stromal cell-derived retinoic acid can directly induce the expression of gut-homing molecules on proliferating T cells, a process strongly enhanced by bone marrow-derived dendritic cells in vitro. Therefore, cooperation of sessile lymph node stromal cells with mobile dendritic cells warrants the imprinting of tissue specific homing receptors on activated T cells. The Journal of Immunology, 2009, 183: 6395-6402.
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