期刊
JOURNAL OF IMMUNOLOGY
卷 183, 期 10, 页码 6320-6329出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0900975
关键词
-
类别
资金
- National Natural Science Foundation of China [30530700, 30623003, 30600568, 30721065, 90713044, 30600308, 30801011, 30870126]
- CAS project [KSCX1-YW-R-43]
- SIBS [2007KIP301]
- Ministry of Science and Technology [2006CB504300, 2007CB512404, 2006AA02A247, 20072714]
- Technology Commission of Shanghai Municipality [88014199, 07DZ22916, 07XD14033, 064319034, 08431903004, 2008ZX10206, OSDZ2291703]
- EU [FP6-2005-SSP-5-B, SP5B-CT-2006-044161]
- National Basic Research Program of China (973 Program) [2007CB513001]
- E-institutes of Shanghai Universities Immunology Division
Th cell differentiation is precisely regulated by thousands of genes at different stages. In the present study, we demonstrate that Dec2, a transcription factor belonging to the bHLH (basic helix-loop-helix) superfamily, is progressively induced during the course of Th2 differentiation, especially at the late stage. The up-regulated Dec2 can strongly promote Th2 development under Th2-inducing conditions, as evidenced by retrovirus-mediated gene transfer or transgenic manipulation. In addition, an enhancement of Th2 responses is also detectable in Dec2 transgenic mice in vivo. Conversely, RNA interference-mediated suppression of endogenous Dec2 could attenuate Th2 differentiation. Finally, we show that the enhanced Th2 development is at least in part due to substantial up-regulation of CD25 expression elicited by Dec2, thereby resulting in hyperresponsiveness to IL-2 stimulation. The Journal of Immunology, 2009, 183: 6320-6329.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据