期刊
JOURNAL OF IMMUNOLOGY
卷 182, 期 2, 页码 890-901出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.182.2.890
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资金
- National Health and Medical Research Council (NHMRC) of Australia
- Cancer Institute, New South Wales (NSW)
- University of Sydney
- Cancer Institute NSW Research Scholar Award
Enhanced secondary Ab responses are a vital component of adaptive immunity, yet little is understood about the intrinsic and extrinsic regulators of naive and memory B cells that result in differences in their responses to Ag. Microarray analysis, together with surface and intracellular phenotyping, revealed that memory B cells have increased expression of members of the TNF receptor, SLAM (signaling lymphocytic activation molecule), B7, and Bcl2 families, as well as the TLR-related molecule CD180 (RP105). Accordingly, memory B cells exhibited enhanced survival, proliferation, and Ig secretion, and they entered division more rapidly than did naive B cells in response to both T cell-dependent and T cell-independent stimuli. Furthermore, both IgM and isotype-switched memory B cells, but not naive B cells, costimulated CD4(+) T cells in vitro through a mechanism dependent on their constitutive expression of CD80 and CD86. This study demonstrates that up-regulation of genes involved in activation, costimulation, and survival provides memory B cells with a unique ability to produce enhanced immune responses and contributes to the maintenance of the memory B cell pool. The Journal of Immunology, 2009, 182: 890-901.
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