期刊
JOURNAL OF IMMUNOLOGY
卷 183, 期 1, 页码 51-58出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0802047
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资金
- National Health and Medical Research Council [351439]
- Cancer Council Queensland [Q42]
- Australian Cancer Research Foundation
- Cancer Research Institute, New York
- University of Queensland
- Lions Research Foundation
- Queensland Government
Ags characterizing tumors or chronic viral infection are generally presented to the host immune system before specific immunotherapy is initiated, and consequent generation of regulatory CD4(+) T cells can inhibit induction of desired effector CD8 T cell responses. IL-10 produced in response to ongoing Ag exposure inhibits generation of CD8 T cells in an Ag-experienced host. We now show that this IL-10 is produced by Ag experienced CD4(+) glucocorticoid-induced tumor necrosis factor receptor(+) T cells that also secrete IFN-gamma upon antigenic stimulation, that IL-10 secretion by these cells is enhanced through IFN-gamma signaling, and, unexpectedly, that IFN-gamma signaling is required for inhibition of generation of Ag-specific CD8 T cell responses in an Ag-experienced host. Systemic inhibition of both IL-10 and IFN-gamma at the time of immunization may therefore facilitate induction of effective immunotherapeutic responses against tumor specific and viral Ags. The Journal of Immunology, 2009, 183: 51-58.
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