期刊
JOURNAL OF IMMUNOLOGY
卷 182, 期 12, 页码 7473-7481出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0802831
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资金
- Dutch Cancer Society [NKI 2001-2415]
- Landsteiner Foundation for Blood Research [0533]
- Netherlands Organization for Scientific Research
The present paradigm is that primary B cells are nonphagocytosing cells. In this study, we demonstrate that human primary B cells are able to internalize bacteria when the bacteria are recognized by the BCR. BCR-mediated internalization of Salmonella typhimurium results in B cell differentiation and secretion or anti-Salmonella Ab by the Salmonella-specific B cells. In addition, BCR-mediated internalization leads to efficient Ag delivery to the MHC class II Ag-loading compartments', even though Salmonella remains vital intracellularly in primary B cells. Consequently, BCR-mediated bacterial uptake induces efficient CD4(+) T cell help, which boosts Salmonella-specific Ab production. BCR-mediated internalization of Salmonella by B cells is superior over extracellular Ag extraction to induce rapid and specific Immoral immune responses and efficiently combat infection. The Journal of Immunology, 2009, 182: 7473-7481.
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