4.8 Article

Copper-Catalyzed Trifluoromethylation of Polysubstituted Alkenes Assisted by Decarboxylation

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ORGANIC LETTERS
卷 18, 期 1, 页码 72-75

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03290

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资金

  1. National Basic Research Program of China [2015CB931900, 2012CB215500]
  2. National Natural Science Foundation of China [21372246, 21402227, 21421002]
  3. Shanghai Science and Technology program [15XD1504400]
  4. Chinese Academy of Sciences

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An efficient copper-catalyzed trifiuoromethylation of polysubstituted alkenes assisted by decarboxylation of beta,gamma-unsaturated carboxylic acids has been achieved. The reaction provides a general method to construct allylic and vinylic CF3-substituted compounds under mild conditions.

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