期刊
JOURNAL OF IMMUNOLOGY
卷 183, 期 8, 页码 4848-4852出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0900848
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资金
- National Cancer Institute, National Institutes of Health
- Department of Defense Prostate Cancer Research Program [N01-CO-12400]
We previously reported that naive, tumor-specific CD8(+) (TcR-I) T cells transferred into prostate tumor-bearing mice traffic to the prostate where they become tolerized. We now report that TcR-I cells suppress the proliferation of naive T cells. This suppression is mediated at least in part by secreted factors, and the suppressive activity can be blocked by Abs directed against TGF-beta. We further report that TcR-I cells must infiltrate the prostate to acquire suppressive activity. Delivery of tumor-specific CD4(+) T cells prevents the conversion of TcR-I cells into suppressor cells. Taken together, our findings may have critical implications for sustaining T cell responsiveness during immunotherapy, as the development of suppressor cells in the tumor microenvironment may eliminate the potency of T cells primed in the periphery or delivered during adoptive immunotherapy. The Journal of Immunology, 2009, 183: 4848-4852.
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