期刊
JOURNAL OF IMMUNOLOGY
卷 181, 期 5, 页码 3456-3463出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.181.5.3456
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资金
- Ministry of Education. Culture, Sports, Science and Technology of Japan
- Japan Society for Promotion of Science
- Takeda Science Foundation
IL-17A is originally identified as a proinflammatory cytokine that induces neutrophils. Although IL-17A production by CD4(+) Th17 T cells is well documented, it is not clear whether IL-17A is produced and participates in the innate immune response against infections. In the present report, we demonstrate that IL-17A is expressed in the liver of mice infected with Listeria monocytogenes from an early stage of infection. IL-17A is important in protective immunity at an early stage of listerial infection in the liver because IL-17A-deficient mice showed aggravation of the protective response. The major IL-17A-producing cells at the early stage were TCR gamma delta T cells expressing TCR V gamma 4 or V gamma 6. Interestingly, TCR gamma delta T cells expressing both IFN-gamma and IL-17A were hardly detected, indicating that the IL-17A-producing TCR gamma delta T cells are distinct from IFN-gamma-producing gamma delta T cells, similar to the distinction between Th17 and Th1 in CD4(+) T cells. All the results suggest that IL-17A is a newly discovered effector molecule produced by TCR gamma delta T cells, which is important in innate immunity in the liver.
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