期刊
JOURNAL OF IMMUNOLOGY
卷 181, 期 12, 页码 8761-8766出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.181.12.8761
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资金
- National Institutes of Health [RO1 AI42269, RO1 AI49954]
- Mary Kirkland Center
- Hospital for Special Surgery
Double negative (DN) T cells are expanded in patients with systemic lupus erythematosus (SLE) and stimulate autoantibody production as efficiently as CD4(+) T cells. In this study, we demonstrate that DN T cells from patients with SLE produce significant amounts of IL-17 and IFN-gamma, and expand when stimulated in vitro with an anti-CD3 Ab in the presence of accessory cells. Furthermore, IL-17(+) and DN T cells are found in kidney biopsies of patients with lupus nephritis. Our findings establish that DN T cells produce the inflammatory cytokines IL-17 and IFN-gamma, and suggest that they contribute to the pathogenesis of kidney damage in patients with SLE. The Journal of Immunology, 2008, 181: 8761-8766.
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