期刊
JOURNAL OF IMMUNOLOGY
卷 180, 期 10, 页码 6472-6476出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.180.10.6472
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资金
- NCI NIH HHS [CA 081261, R01 CA081261, R01 CA081261-09] Funding Source: Medline
- NIAID NIH HHS [R01 AI048073, N01 AI 40023, AI 076972, R01 AI076972-02, R01 AI048073-08, R01 AI057840, AI 057840, U54 AI 065359, N01AI40023, R01 AI057840-04, U54 AI065359, R01 AI076972, AI 048073] Funding Source: Medline
- PHS HHS [HHSN 26620040006C] Funding Source: Medline
CD4 T lymphocytes regulate the adaptive immune response to most viruses, both by providing help to CD8 T cells and B cells as well as through direct antiviral activity. Currently, no mouse cytomegalovirus (MCMV)-specific CD4 T cell responses are known. In this study, we identify and characterize 15 I-A(b)-restricted CD4 T cell responses specific for MCMV epitopes. CD4 T cells accumulate to high levels in the spleen and lungs during acute infection and produce multiple cytokines (IFN-gamma, TNF, IL-2, IL-10, and IL-17). Interestingly, IL-17 and IFN-gamma production within epitope-specific cells was found to he mutually exclusive. CD4 T cells recognizing a peptide derived from m09 were only detectable at later times of infection and displayed a unique cytokine production profile. In total, this study reveals that the MCMV-specific CD4 T cell response is complex and functionally diverse, highlighting its important role in controlling this persistent pathogen.
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