Direct C-H Trifluoromethylation of Glycals by Photoredox Catalysis

A Mild, efficient, and practical transformation for the direct C-H,trifluotoni-ethylation:of glycals under visible light has been reported for the first time This reaction employed fac-Ir3+ (ppy)(3) as the photocatalyst) Urnemo's reagent as the CF3 source, and a household blue Letp or sunlight as the light source. Glycals bearing both withdrawing and -donating protective groups performed this reaction smoothly: This visible ligilit-mediated trifluomethylation reaction was highlighted by the trifluoromethlyation of the biologically important Neu2en moiety.