期刊
JOURNAL OF IMMUNOLOGY
卷 181, 期 10, 页码 6697-6701出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.181.10.6697
关键词
-
类别
资金
- Trudeau Institute
- National Institutes of Health [AI61570, AI074878, AI32573, AI072296, AI076479]
Infections with helminth parasites are associated with an IgE isotype switch and high serum IgE concentrations. IgE is rapidly bound by the high affinity IgE receptor (Fc epsilon RI), thereby sensitizing Fc epsilon RI-bearing basophils and mast cells for. IgE-inducible effector functions such as IL-4 production. The development of Absecreting B cells is dependent on IgM and consequently, mu MT mice, which lack surface IgM, are considered devoid of Abs. In this study we report the unexpected finding that C57BL/6 mu MT mice generate robust IgE responses upon infection with three distinct helminth parasites, Heligmosomoides polygyrus, Trichuris muris, and Schistosoma mansoni. IgE is produced despite an apparent block in B cell development and licenses basophils for IgE-induced IL-4 production. Our findings reveal the existence of an evolutionarily conserved, IgM-independent pathway for the production of IgE upon infection with helminth parasites. The Journal of Immunology, 2008, 181: 6697-6701.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据