期刊
ORGANIC LETTERS
卷 17, 期 20, 页码 5052-5055出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02527
关键词
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资金
- Natural Science Foundation of China [21373073]
- Young National Natural Science Foundation of China [21302033, 21302032]
- PCSIRT [IRT 1231]
- Hangzhou Normal University
- Hangzhou City
- Zhejiang Province in China
An N-heterocyclic carbene-catalyzed highly enantioselective [3 + 3] annulation reaction of N-hydroxyphthalimide (NHPI) 3,3-disubstituted acrylates and N-Ts ketimines was developed. In most cases, the desired chiral dihydropyridinone products bearing an all carbon quaternary stereogenic center could be obtained in good yields with excellent enantioselectivities (>99% ee's), which demonstrated the NHPI acrylates as a kind of excellent substrate in NHC-catalysis.
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