4.8 Article

Unexpected Synthesis of 5,6-Dihydropyridin-2(1H)-ones by a Domino Ugi/Aldol/Hydrolysis Reaction Starting from Baylis-Hillman Phosphonium Saks

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ORGANIC LETTERS
卷 17, 期 9, 页码 2234-2237

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00849

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资金

  1. National Natural Science Foundation of China [21172085]
  2. Hubei University of Medicine [2014CXZ01]
  3. Hubei Key Laboratory of Wudang Local Chinese Medicine Research of Hubei University of Medicine [WDCM009]

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A one-pot synthetic approach to 5,6-dihydropyridin-2(1H)-ones has been developed using a domino process involving Ugi, aldol, and hydrolysis reactions, starting with Baylis-Hillman phosphonium salts, primary amines, isocyanides, and arylglyoxals.

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