期刊
ORGANIC LETTERS
卷 17, 期 17, 页码 4336-4339出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02160
关键词
-
资金
- NSF of China [21125209, 21332003, 21402051]
- MOST of China [2011CB808600]
- STCSM [12JC1403800]
A Rh(II)/chiral phosphoric acid cocatalyzed four-component reaction of indoles, 3-diazooxindoles, arylamines, and ethyl glyoxylate is developed, offering an extremely efficient strategy for the construction of 3,3-disubstituted 3-indol-3'-yloxindoles with excellent diastereoselectivities and high to excellent enantioselectivities. This transformation is proposed to proceed through a Mannichtype trapping of the zwitterionic intermediate generated from a metal carbene and an indole with an iminoester derived from an arylamine and a glyoxylate.
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