期刊
ORGANIC LETTERS
卷 17, 期 16, 页码 3990-3993出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01842
关键词
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资金
- National Project BIT3G-Italian Green Chemistry Cluster
- University of Perugia
- Regione Toscana
Phenols can be efficiently reduced by sodium formate and Pd/C as the catalyst in water and in the presence of amines to give the corresponding cydohexylamines. This reaction works at rt for 12 h or at 60 degrees C under mictowave dielectric heating for 20 min. With the exception of aniline, primary, secondary amines, amino alcohols, and even amino acids can be used as nucleophiles. The reductive process is based on a sustainable hydrogen source and a catalyst that can be efficiently recovered and reused. The protocol was developed into a continuous-flow production of cyclohexyl-amines in gram scale achieving very efficient preliminary results (TON 32.7 and TOF 5.45 h(-1)).
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