期刊
ORGANIC LETTERS
卷 18, 期 2, 页码 288-291出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03458
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资金
- National Nature Science Foundation of China [21302124, 21232004]
- China Postdoctoral Science Foundation [2012M520882]
- Shanghai Chenguang Project [14CG11]
- Science and Technology Commission of Shanghai Municipality [14XD1402300]
A Pd(II)/Pyrox-catalyzed enantioselecitve addition of arylboronic acids to 3-ketimino oxindoles was developed, providing chiral 3-amino-2-oxindoles with a quaternary stereocenter in high yields and with good enantioselectivities. A variety of functionalized 3-ketimino oxindoles can be used, and the method tolerates some variation in arylboronic acid scope. This asymmetric arylation provides an alternative efficient catalytic method for the preparation of chiral 3-aryl-3-amino-2-oxindoles, which also represents the first example of a Pd(II)-catalyzed addition of arylborons to exocyclic ketimines.
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