期刊
JOURNAL OF IMMUNOLOGICAL METHODS
卷 377, 期 1-2, 页码 53-55出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jim.2012.01.003
关键词
Cell-mediated immunity; Herpes zoster; Varicella-zoster virus; Vaccine; IFN-gamma
资金
- Grants-in-Aid for Scientific Research [23591486] Funding Source: KAKEN
Though cell-mediated immunity (CMI) against varicella-zoster virus (VZV) is critical for prevention of the onset of herpes zoster (HZ), clinicians currently lack a simplified procedure to monitor CMI. We have recently developed an assay, called the IFN-gamma release assay, and showed that it is a simple and reliable method to determine VZV-specific CMI. In the present study, we applied an IR assay to measure the VZV-specific CMI of patients with HZ. VZV-specific CMI levels were significantly high at the onset of the disease, but were decreased several weeks later. In contrast, CMI VZV-specific antibody titers increased in convalescent phase compared to those in acute phase. Thus, this technology is likely to be very useful in monitoring ongoing VZV-specific immune status. (C) 2012 Elsevier B.V. All rights reserved.
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